สารบัญ

Thai name เซรุ่มแก้พิษงูระบบโลหิตชนิดรวม(SERUM KAE PHIT NGU RABOP LOHIT CHANID RUAM)

Category Passive immunizing agent.

          Hematotoxic Polyvalent Antivenin is a sterile preparation containing the specific antitoxic globulins from immunized animals. It has the power of neutralizing the green pit viper (Trimeresurus albolabris) venom, the Malayan pit viper (Calloselasma rhodostoma) venom, and the Russell’s viper (Daboia russelii siamensis) venom.

          The antivenin, reconstituted if necessary as stated on the label, complies with the requirements stated under Antisera, with the following modifications.

Description Colourless or slightly yellowish brown transparent liquid. Freeze-dried antivenin consists of solid exhibiting the characteristic structure of a freezedried solid, light cream in colour.

Expiration date; Warning See under Cobra Antivenin, p. 232.

Labelling Complies with the “General Information for Antisera”, p. 225. In addition the label on the container states (1) the number in mg of reference green pit viper venom, reference Malayan pit viper venom, and reference Russell’s viper venom, neutralized by a specified quantity of the antivenin; (2) the recommended human dose; (3) the nature of the preparation, e.g. natural serum or purified immunoglobulin or treated immunoglobulin and, if purified or treated, the nature of the process.

Identification Specifically neutralizes the green pit viper venom, the Malayan pit viper venom, and the Russell’s viper venom, rendering it harmless to susceptible animals. The assay may serve as an identification test.

Assay Each ml contains sufficient antitoxic globulins to neutralize the amount of the green pit viper venom, the Malayan pit viper venom, and the Russell’s viper venom stated on the label when determined by the “Biological Assay of Cobra Antivenin” (Appendix 15.2.7); use the green pit viper test venom, the Malayan pit viper test venom, and the Russell’s viper test venom, for determining its capacity to neutralize the lethal effect.

          Usual dose Initial dose 20 ml of liquid or freeze-dried Hematotoxic Polyvalent Antivenin (after reconstitution by accompanying diluent) should be given by slow intravenous infusion (not more than 1 ml per minute). If symptoms still persist, the second dose should be repeated 2 hours or even earlier after the initial dose. The further dose should be repeated every 6 hours according to the clinical symptoms.